Concomitant utilization of benzodiazepines, together with diazepam, and opioids might cause profound sedation, respiratory depression, coma, and death; reserve concomitant prescribing of benzodiazepines and opioids to be used in sufferers for whom substitute therapy alternatives are insufficient; minimize opiate dose a single-third when diazepam is additional
Use of benzodiazepines, which includes diazepam, both equally utilised by itself and together with other CNS depressants, could lead to possibly deadly respiratory melancholy
Voxelotor will increase systemic exposure of sensitive CYP3A4 substrates. Stay away from coadministration with sensitive CYP3A4 substrates that has a narrow therapeutic index. Think about dose reduction of your delicate CYP3A4 substrate(s) if struggling to keep away from.
Keep away from or substitute A further drug for these prescription drugs when probable. Examine for lack of therapeutic impact if medication should be coadministered.
posaconazole will increase the amount or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Steer clear of or substitute another drug for these medicines when achievable. Consider for loss of therapeutic outcome if medication must be coadministered. Alter dose As outlined by prescribing information and facts if desired.
miconazole vaginal will increase the degree or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Reserve concomitant prescribing of those drugs in individuals for whom other procedure alternatives are inadequate. Limit dosages and durations to your minimum necessary. Keep track of closely for indications of respiratory read here melancholy and sedation.
The prescriber have to be convinced from historical reviews and/or personal observations that the individual reveals identifiable traits of seizure cluster which might be distinguished from your patient’s normal seizure action because of the caregiver who'll be answerable for administering diazepam rectal gel
Before use, instruct person administering diazepam intranasal on how to detect seizure clusters and the way to properly administer the product
apalutamide will decrease the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs which are CYP3A4 substrates may result in decrease publicity to these medications.
triclabendazole will improve the stage or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism.
diazepam will enhance the stage or impact of avapritinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Use Warning/Watch. Ethinyl estradiol may well inhibit the clearance of benzodiazepines that endure oxidation, thus rising serum concentrations of concomitantly administered benzodiazepines.